D125 - Bioinorganic chemistry

Course specification
Course titleBioinorganic chemistry
Study programme
Lecturer (for classes)
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      ConditionОблик условљености
      The goalTo gain an understanding of a role of metal ions in biological systems; To learn about the structure and function of several enzymes that activate small molecules; To learn about the goals and methods of chemists that aim to mimic biological systems; To learn about selected organometallic and inorganic complexes that do a good job of mimicking biological catalysis.
      The outcomeUpon successful completion of this course, the student should be able to: ; • Demonstrate proficiency in the basic principles of inorganic chemistry, biochemistry, and molecular biology that are necessary to approach the field of bioinorganic chemistry. ; • Identify the appropriate analytical techniques that are useful in characterizing transition-metal complexes in biological molecules. ; • Describe the different processes involved in the transport and storage of metal ions. ; • Describe the role of metal ions that are involved in electron-transfer reactions in biological systems. ; • Describe the most common metal centers for electron-transfer reactions—those based on copper and iron ions. ; • Summarize the role of metal centers in the enzymes that are involved in the nitrogen cycle. ; • Describe how oxygen is transported through the human body and transferred to each biological entity that requires it; identify which metal centers perform these tasks. ; • Describe the different metal-activation sites in enzymes that are involved in the incorporation of oxygen atoms into bio-organic molecules.
      Contents of lecturesMetals found in biological systems: structure and function; - Review of physical methods as applied to bioinorganic chemistry ; - Proteins as ligands: how the amino acids bind to metals ; - Zinc enzymes: carbonic anhydrase, carboxypeptidase A, phospotriesterase ; - Calcium binding proteins: Calmodulin ; - Hydrogenase and its mimics ; -Oxygen transport and activation: hemocyanin, methane monooxgenase ; - Non heme iron sites in enzymes: ribonucleotide reductase ; - Superoxide Dismutase (including the recently discovered Ni SOD ; - Nitrogenase and its mimics ; - Electron transport proteins: blue copper proteins, cytochrome P450 ; - The role of Co and Ni dependent enzymes in ancient life; Cobalamins: organometallic bonds in enzymes ; - Ni enzymes: Acetyl-CoA Synthase and CO dehydrogenase ; - Student presentations on selected topics ; - Metal containing drugs: cisplatin ; - Metal toxicity: lead and cadmium
      Contents of exercises
      1. J. A. Cowan, Inorganic Biochemistry: An introduction, 2nd Edition, J. Wiley, N.Y., 1997 (ISBN: 0-471-18895-6)
      2. R.M. Roat-Malone, Bioinorganic Chemistry - A Short Course, J. Wiley&Sons, Inc., Hoboken, 2002 (ISBN: 0-471-15976-X)
      Number of hours per week during the semester/trimester/year
      LecturesExercisesOTCStudy and ResearchOther classes
      Methods of teachingLectures, seminar, tests
      Knowledge score (maximum points 100)
      Pre obligationsPointsFinal examPoints
      Activites during lectures20Test paper
      Practical lessonsOral examination50