14MHPI12 - Polymeric Biomaterials

Course specification
Course titlePolymeric Biomaterials
Study programmeChemical engineering
Lecturer (for classes)
Lecturer/Associate (for practice)
Lecturer/Associate (for OTC)
    ConditionNoОблик условљености
    The goalIntroduction to polymeric biomaterials, methods of their synthesis and characterization, and most important applications in medicine, pharmacy and dentistry .
    The outcomeStudents acquire knowledge in the methods of polymer synthesis, their structure, properties and possibilities of application of polymeric biomaterials in medicine, pharmacy and dentistry, and in the design of various medical devices. Based on these skills they are capable to select optimal polymeric biomaterial and method of material synthesis for the desired application.
    Contents of lecturesIntroduction to biomaterials: structural hierarchy in materials & biology. Biomaterials surfaces: physics and chemistry. Physics-surface structure and properties. Chemistry-reactions at surfaces: chemisorption, hydrolysis. Synthesis of biomaterials. Polymers as biomaterials: natural and synthetic polymers. Synthetic polymers. Polysaccharides as biomaterials. Chitosan: structure-property relationship and biomedical applications. Blood-contacting polymers. Polymers for tissue engeeniring scaffolds. Hydrogel for biomedical and pharmaceutical applications. Stimuli-sensitive hydrogels. Polymeric systems for drug delivery. Hydrogels as drug carrier systems. Transdermal delivery of drugs. Drug delivery via mucosal routes. Chitosan-based delivery systems: physicochemical properties and pharmaceutical applications. Polymeric adhesives for medical applications. Bioadhesive drug delivery systems. Dermocosmetic applications of polymeric biomaterials. Biomaterials for organ replacement. Biocompatibility of polymeric biomaterials. Sterilization of medical devices. Medical devices design and regulation.
    Contents of exercisesDemonstration exercises in the synthesis and characterization of materials using modern methods (FTIR, SEM, AFM, TGA and in vitro testing of the SBF). Solving tasks that give insight into the synthesis, properties and characterization of polymers. Solving tasks in the fields of biodegradable polymers, hydrogels and controlled release systems in order to gain a more complete picture of application materials in the field of pharmacy and medicine. Statistical Analysis (Error Sources, Distribution Functions, t- test, Fisher Test, Regression Methods). Homework and seminar essay in the selected area aims to introduce students to the latest developments in the field of literature and analyzing scientific papers to a more comprehensive insight at this area.
    1. С. Томић, Ј. Филиповић, Полимерни биоматеријали, Internal material, OHT Department, Faculty of Technology and Metallurgy, Belgrade, 2013.
    2. Polymeric biomaterials, S. Dimitriu (Ed.), Marcel Dekker, 2013.
    3. Biomaterials-An Introduction, J.B. Park, R.S. Lakes (Eds.), Springer, 2007.
    Number of hours per week during the semester/trimester/year
    LecturesExercisesOTCStudy and ResearchOther classes
    Methods of teachingLessons, consultations, experimental and calculation exercises
    Knowledge score (maximum points 100)
    Pre obligationsPointsFinal examPoints
    Activites during lecturesTest paper60
    Practical lessons10Oral examination