HFI413 - Process Control in Pharmaceutical Industry

Course specification
Course titleProcess Control in Pharmaceutical Industry
Study programme
Lecturer (for classes)
Lecturer/Associate (for practice)
Lecturer/Associate (for OTC)
    ConditionFor attending the course: Computer programming, Mechanical Operations, Heat transfer operations, Mass transfer operations, Basics of reaction engineering; For the exam: Essentials of Process ControlОблик условљености
    The goal1. Recognizing the specific issues related to control of pharmaceutical processes. ; 2. Learning about modern methods for control of pharmaceutical processes. ; 3. Learning about the specific demands regarding the instrumentation used in pharmaceutical industry ;
    The outcomeAfter this course the students will be able to: ; - Work in automated plants of pharmaceutical industry. ; - Specify and define the necessary instrumentation for control systems in pharmaceutical industry. ; - Work in specialized teams for designing control systems for pharmaceutical industry. ;
    Contents of lecturesSpecific issues of control of pharmaceutical processes (batch and semi-batch processes, CIP and SIP, demands regarding sanitary conditions); dynamics of characteristic processes for pharmaceutical industry. ; 2. Advanced systems of process control based on feedback systems: cascade control, selective control, split-range control, feedback-feedforward control. ; 4. Digital control systems: analog and digital signals, discrete dynamic models, discrete controllers, digital equipment in control systems. ; 5. Practical aspects: specific applications of control systems for some typical processes in pharmaceutical industry; different levels of digital control (monitoring and data acquisition, DDC, SCADA, DSC). ;
    Contents of exercisesExercises in a computer laboratory, using MATLAB and its additions: Control System Toolbox, Simbolic Math Toolbox and Simulink. Two project assignments.
    1. Menka Petkovska, “Merenje i upravljanje u procesnim sistemima sistemima”, TMF, Beograd 2007 (Original title)
    2. Materijali sa predavanja, Materijali za vežbe, u elektronskom obliku (Original title)
    3. Anthony Hickey, David Ganderton, “Pharmaceutical Process Engineering”, Marcel Dekker, Basel, 2001 (Original title)
    4. George Buckbee, Joseph Alford, Automation applications in Bio-Pharmaceuticals, ISA, Research Triangle Park, NC, 2008 (Original title)
    Number of hours per week during the semester/trimester/year
    LecturesExercisesOTCStudy and ResearchOther classes
    Methods of teachingTheoretical lessons with simple examples, exercises in the computer laboratory, project assignments, consultations
    Knowledge score (maximum points 100)
    Pre obligationsPointsFinal examPoints
    Activites during lecturesTest paper50
    Practical lessonsOral examination