D126 - Immobilized biocatalysts: immobilization techniques, bioreactors and applications

Course specification
Course title		Immobilized biocatalysts: immobilization techniques, bioreactors and applications
Acronym		D126
Study programme
Module
Lecturer (for classes)		prof. dr Bojana Obradović prof. dr Zorica Knežević-Jugović
Lecturer/Associate (for practice)		prof. dr Bojana Obradović prof. dr Zorica Knežević-Jugović
Lecturer/Associate (for OTC)
ESPB		6.0	Status
Condition		none	Облик условљености
The goal		The aim of the course is to teach the students specialized and novel trends and achievements in the area of bioreactor systems with immobilized cells and enzymes specifically applied in biotechnological processes, pharmacy, biomedicine, organic synthesis, environmental engineering and other fields. The goal is also to prepare the students for experimental research in this area during the laboratory studies of different biocatalyst carriers, immobilization methods and a selected bioreactor system with immobilized cells/enzyme with respect to the operating regime and the process efficiency.
The outcome		1. Students extended their knowledge and gained new insights in the current immobilized systems, which are increasingly applied in biotechnological processes, pharmacy, medicine and diagnostics. ; 2. Students gained skills and knowledge to critically analyze and evaluate different immobilization techniques as well as to independently develop new immobilized systems suited for the specific application. ; 3. Students gained competencies to independently design and carry out an experimental plan and to analyze and present the obtained results. ; 4. Students gained communication and social competencies required for work in a team of engineers.
Contents
Contents of lectures		The course introduces to students modern bioreactor systems with immobilized cells and enzymes, which are widely applied in different areas of biotechnology, pharmacy, biomedicine and wastewater treatment processes. The course topics include a review of types and properties of commercial immobilization carriers, theoretical principles and practical utilization of classical and novel immobilization techniques, and the analysis of the main immobilized bioreactor types regarding hydrodynamics, mass transfer properties, design parameters, and practical applications. The course also introduces to students recent trends in development of novel immobilized systems and possibilities for utilization in practice in different areas.
Contents of exercises		The course includes experimental research so that the students investigate different immobilization carriers and techniques, and then set up and test a selected bioreactor system with immobilized cells/enzyme with respect to the operating regime and the process efficacy.
Literature
Z. Knežević-Jugović “Enzyme engineering” (in Serbian), Faculty of Technology and Metallurgy, Belgrade, 2008. L. Cao, Carrier-bound immobilized enzymes: Principles, Applications and Design, Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany, 2005. R.F. Taylor, Protein immobilization: Fundamentals and application, Marcel Dekker Inc., New York, 2001. Fundamentals of Cell Immobilisation Biotechnology, Focus on Biotechnology, Vol. 8a, V. Nedovic and R.G. Willaert (eds.), Kluwer Academic Publishers, Dordrecht, 2004. Bioreactor immobilized enzymes and cells. Fundamentals and applications, M. Moo-Young (ed.), Elsevier Applied Science, London and New York, 1988.
Number of hours per week during the semester/trimester/year
Lectures	Exercises	OTC	Study and Research	Other classes
2	1
Methods of teaching		theoretical lessons and laboratory research
Knowledge score (maximum points 100)
Pre obligations		Points	Final exam	Points
Activites during lectures			Test paper
Practical lessons			Oral examination	35
Projects
Colloquia
Seminars