14HFI48 - Design of devices and apparatus in pharmaceutical industry

Course specification
Course titleDesign of devices and apparatus in pharmaceutical industry
Study programmeChemical Engineering
Lecturer (for classes)
Lecturer/Associate (for practice)
Lecturer/Associate (for OTC)
    Condition-Облик условљености
    The goalThis course is continuation of the course Introduction in design. The aim is to extend the theoretical and practical knowledge necessary for design of devices and apparatus in pharmaceutical industry.
    The outcomeThrough the planned syllabus, computational exercises and project assignment, students gain knowledge about dimensioning and detailed design of devices and apparatus which are working under conditions of high or low temperature, overpressure or vacuum in pharmaceutical plants. Students will be able to apply this knowledge in engineering practice, through the analysis of the design phases.
    Contents of lecturesDefinition of apparatus in the process industry. Basic design principles of equipment structure: influence of technological requirements, design and possibilities for production and assembly, customization of structure in order to meet the requirements in pharmaceutical industry (GMP, FDA, national standards and regulations). Typical and dedicated equipment in pharmaceutical industry. Pressurized equipment – overview of categories according to European PED. The influence of location factors and assembly. Safety factor. ; Determination of volume and geometric measures of apparatus. The requirements which have to be fulfilled in design of devices and apparatus according to SRPS EN standards. Thin-walled and thick-walled equipment structure. Stress state of thin-walled apparatus. Definition of number and positions of openings on the apparatus (nozzles, opening for stirrer, inspection openings). Sealing problems in apparatus working in sterile production conditions. Devices for solid dosage forms production in pharmaceutical industry. Characteristics of fluid transport through pipelines in pharmaceutical industry. Basics of pneumatic transport design for solid forms (powders and granules).
    Contents of exercisesComputational exercises include examples of design of apparatus structures in pharmaceutical industry: ; 1. Dimensioning of jacketed pressure vessel - bioreactor, ; 2. Design of mechanical stirrer and sealing of the stirrer shaft, ; 3. Dimensioning of storage tank, and ; 4. Dimensioning of pipeline and the auxiliary equipment.
    1. Predavanja predmetnih nastavnika i materijal sa računskih vežbi (Original title)
    2. B. Bugarski, Projektovanje procesa i uređaja u biotehnologiji i biohemijskom inženjerstvu, Akademska misao, Beograd, 2005. (Original title)
    3. M. Rakin, S. Putić, N. Tomović, B. Gnjatović, Oprema u farmaceutskom inženjerstvu, priručnik, Tehnološko-metalurški fakultet, Univerzitet u Beogradu, 2010. (Original title)
    4. M. Isailović, M. Bogner, Tehnički propisi o posudama pod pritikom, SMEITS, Beograd, 2003. (Original title)
    5. J.L. Couper, W. Roy Penney, J.R. Fair, S. Walas, Chemical Process Equipment Selection and Design, Elsevier - Gulf Professional Publishing, 2005. (Original title)
    6. Standard SRPS EN 13445, Institut za standardizaciju Srbije, Beograd, 2010. (Original title)
    7. C. Matthews, Engineers' guide to pressure equipment, Professional Engineering Publishing, London, 2001. (Original title)
    8. S. C. Gad, Pharmaceutical manufacturing handbook, production and processes, Wiley, 2008. (Original title)
    Number of hours per week during the semester/trimester/year
    LecturesExercisesOTCStudy and ResearchOther classes
    Methods of teachingLectures in the classroom (using computer and video beam, overhead projector and blackboard). Work on project completion using licensed CAD software packages in small groups.
    Knowledge score (maximum points 100)
    Pre obligationsPointsFinal examPoints
    Activites during lectures10Test paper
    Practical lessons30Oral examination40