14HFI415 - The Principles of Medicine Synthesis in Pharmaceutical Engineering

Course specification
Course titleThe Principles of Medicine Synthesis in Pharmaceutical Engineering
Study programmeChemical Engineering
Lecturer (for classes)
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      ConditionOrganic Chemistry I and IIОблик условљености
      The goalIntroducing students to the basic principles of the study of medicine synthesis, from the choice of the pharmacologically active substance, through research and planning to development which consists of the optimization of synthetic procedure from laboratory conditions to industrial synthesis.
      The outcomeThe students should become acquainted with basic medicine synthesis in pharmaceutical industry, over research and development to the industrial production.
      Contents of lecturesThe course introduces students with basic principle – the choice of the reaction route, reactants, solvents, reaction's nature and conditions, purification of the product etc.) with the accent on the methods of obtaining optically clean substances. Chemical methods, stereoselectivity and catalysis will be taken into account, as well as the use of enzymes. Students get to know the asymmetric synthesis from the examples from industrial practice, based on the new stereochemical methods. The new QSAR methods and the necessary AMET characteristics will also be exaplained. ; ;
      Contents of exercisesThe synthesis of pharmacologically active substances which follows the literature work, tracing the reaction course and the up-to-date product identification.
      1. Ž. Čeković, Organske sinteze, reakcije i metode, Zavod za udžbenike i nastavna sredstva, 2006. Beograd. (Original title)
      2. N. Raos, S. Raić-Malić, M. Mintas, Lekovi u prostoru, farmakofori i receptori, Školska knjiga Zagreb 2005. Zagreb. (Original title)
      3. The Art of Drug Synthetis, ed. By D. S. Johnson, J. J: Li, J. Wiley 2007. USA (Original title)
      Number of hours per week during the semester/trimester/year
      LecturesExercisesOTCStudy and ResearchOther classes
      Methods of teachingLectures and laboratory practice.
      Knowledge score (maximum points 100)
      Pre obligationsPointsFinal examPoints
      Activites during lectures30Test paper
      Practical lessons20Oral examination50