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14BBI485 - Process design in bioprocess and pharmaceutical engineering

Course specification
Course titleProcess design in bioprocess and pharmaceutical engineering
Acronym14BBI485
Study programmeBiochemical Engineering and Biotechnology
Module
Lecturer (for classes)
    Lecturer/Associate (for practice)
      Lecturer/Associate (for OTC)
        ESPB5.0Status
        ConditionPhysical chemistryОблик условљености
        The goalIIntroduction of students to the basics of the process design, process scheme, sources of ; information for equipment and process design, material and energetic balances for process and ; equipment. Designe of CIP and SIP process, selection and designe of equipment for upstream, ; conversion and downstream procesess. Introduction to the use of Super Pro Designer for ; proces designe (WFI, pharmaceutical intermediar, proteine production and purification). ; Special care is given to the equipment for work in the sterile conditions. ;
        The outcomeStudents are enabled to correctly select particular equipment, dispose unit operations in ; optimal order, develop process scheme, solve material and energetic balances and perform ; technoeconomic analyze of process. Students are enabled to use Super Pro Designer for ; process design. Introduction of students in team work for better insight of role of engineer in ; project team. Enabling of students for project presentation in PowerPoint. ;
        Contents
        Contents of lecturesProcess design, sources of information, P&I diagrams, scale up, standard and special-purpose equipment. Pipeline design, valve and pump selection, mixers, liofilizators for work in sterile conditions, different air classes in manufacturing zones CIP and SIP. Application of Super Pro Designer for preparation of process documentation.
        Contents of exercisesCalculation and selection of process equipment (bioreactors, separators, membrane separators, pipes, valves, pumps, chromatography). Selection and design of equipment for CIP and SIP. Use of Super Pro Designer for process scheme development and techno economical analyze.
        Literature
        1. Bioprocesno inženjerstvo, M. Milivojević, V. Đorđević, B. Bugarski, V. Nedović, Akademska Misao 2013. ; ; (Original title)
        2. Projektovanje procesa u Buiotehnologiji i bihemiskom inžinjerstvu , B.Bugarski , 2006, Akademska misao. (Original title)
        3. A. Hickey and D. Ganderton, Pharmaceutical Process Engineering, (Original title)
        4. M. Levin, Pharmaceutical Process Scale-Up (Original title)
        5. J. R. Couper, W. R. Penney , J. R. Fair, S. Walas Chemical Process Equipment, Second Edition: Selection and Design (Original title)
        Number of hours per week during the semester/trimester/year
        LecturesExercisesOTCStudy and ResearchOther classes
        23
        Methods of teaching
        Knowledge score (maximum points 100)
        Pre obligationsPointsFinal examPoints
        Activites during lecturesTest paper
        Practical lessonsOral examination40
        Projects
        Colloquia30
        Seminars