BBI313 - Equipment in Biotechnology

Course specification
Course titleEquipment in Biotechnology
Study programme
Lecturer (for classes)
Lecturer/Associate (for practice)
Lecturer/Associate (for OTC)
    ConditionElements of Equipment in Process Industry Облик условљености
    The goalThe objective of the course is to get the students familiar with the basic design solutions, working principles, selection methods and exploitation of equipment in biotechnology.
    The outcomeThrough the planned syllabus, calculation examples and project assignment, students gain adequate knowledge about equipment in biotechnology and its exploitation. Students will be able to apply this knowledge in engineering practice.
    Contents of lecturesClassification of equipment in biotechnology. Basic principles of equipment selection. Current technical regulative. Pressurized equipment. Selection of structural materials for equipment in biotechnology. Types of corrosion-resistant materials; examples of application of stainless steel, alloy non-ferrous metals, non-metallic materials, composite materials and their joints. The risk of product contamination under the influence of structural material. Classification and basic design solutions of bioreactors. Selection of appropriate design depending on the defined process. Different solutions of mechanical stirring in bioreactors. Types of stirrers, stirrer selection and necessary data for calculation. Equipment for sterilization. Sterilization procedure for production area, process air and culture medium. Overview of implemented design solutions of equipment for thermal, mechanical and chemical sterilization. Overview of equipment for grinding. Design solutions and working principles of equipment for separation. Equipment for homogenization. Overview of structural solutions for drying equipment in biotechnology. Selection principles. Equipment for biotechnological processes in the energy sector. Construction solutions and working principle of the digestors and auxiliary equipment for storage and distribution. Construction, operating principles and selection of measurement, regulation and safety elements. Connecting separate entities and assembly of the technological lines in biotechnology production. Examples of constructed plants. Exploitation and maintenance of equipment. Designed life and safety. Factors that influence the occurrence of equipment damage. Stress corrosion problems.
    Contents of exercisesAnalysis of the implemented solutions of equipment in biotechnology. Dimensioning and basic calculations of bioreactor - jacketed pressure vessel. Example of storage tank design in the biotechnology plant. Implemented examples of auxiliary devices and their dimensioning. Calculation of autoclave and the selection of measurement and safety devices.
    1. Pisani izvodi sa predavanja (handouts) i materijal sa vežbi (Original title)
    2. S. Sedmak, S. Putić, Lj. Milović, M. Zrilić, M. Rakin, Praktikum za konstruisanje opreme u procesnoj industriji, Tehnološko-metalurški fakultet, Univerzitet u Beogradu, 2006. (Original title)
    3. Technology Transfer in Biotechnology From Lab to Industry Production - with contributions by numerous experts, Series: Advances in bioshemical Engineering / Biotechnology, vol.92, Kragl Udo (Ed.), 2005. (Original title)
    4. G. Saravakos and A. Kostaropoulos, Handbook of Food Processing Equipment, Kluwer Academic Publishers, 2002. (Original title)
    5. S. Sedmak, M. Nikolić, V. Vojnović, Priručnik za konstruisanje procesne opreme, Tehnološko-metalurški fakultet, Univerzitet u Beogradu, 1994. (Original title)
    6. M. Kuburović, M. Stanojević, Biotehnologija, SMEITS, Beograd, 1997. (Original title)
    Number of hours per week during the semester/trimester/year
    LecturesExercisesOTCStudy and ResearchOther classes
    Methods of teachingLectures in the classroom (using computer and video beam, overhead projector and blackboard). Computational exercises from the practical part solved using licensed MS Office and CAD software packages on PCs. Preparation of students for seminar work completion in small groups.
    Knowledge score (maximum points 100)
    Pre obligationsPointsFinal examPoints
    Activites during lectures10Test paper
    Practical lessonsOral examination40