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22FI48 - Principles of Drug Synthesis in Pharmaceutical Engineering

Course specification
Course titlePrinciples of Drug Synthesis in Pharmaceutical Engineering
Acronym22FI48
Study programme
Module
Lecturer (for classes)
    Lecturer/Associate (for practice)
      Lecturer/Associate (for OTC)
        ESPB4.0Status
        ConditionOrganic Chemistry I and IIОблик условљености
        The goalIntroduce students to the fundamental principles of drug synthesis, from choosing pharmacologically active substances to designing and conducting the research as well as scaling up the synthetic procedure from laboratory conditions to industrial synthesis.
        The outcomeThe students will become acquainted with fundamental drug synthesis in the pharmaceutical industry as well as research and development for industrial production.
        Contents
        Contents of lecturesThe course introduces students to the basic principles of drug synthesis, including but not limited to chemical nature and reaction mechanism, the choice of the reaction route, reactants, solvents, and product purification. The course emphasizes the methods for preparing optically clean substances. It also covers chemical methods, stereoselectivity, and catalysis, as well as the application of enzymes. Students will be introduced to asymmetric synthesis through examples from industrial practice following new stereochemical methods. The course also includes an explanation of new QSAR methods as well as the fundamental AMET characteristics of drugs.
        Contents of exercisesStudents will synthesize pharmacologically active substances according to a literature survey and follow the reaction course using modern instrumental methods for product identification.
        Literature
        1. Ž. Čeković, Organske sinteze, reakcije i metode, Zavod za udžbenike i nastavna sredstva, 2006. Beograd.
        2. N. Raos, S. Raić-Malić, M. Mintas, Lekovi u prostoru, farmakofori i receptori, Školska knjiga Zagreb 2005. Zagreb.
        3. The Art of Drug Synthetis, ed. By D. S. Johnson, J. J: Li, J. Wiley 2007. USA
        Number of hours per week during the semester/trimester/year
        LecturesExercisesOTCStudy and ResearchOther classes
        22
        Methods of teachingLectures and laboratory practice.
        Knowledge score (maximum points 100)
        Pre obligationsPointsFinal examPoints
        Activites during lectures30Test paper
        Practical lessons20Oral examination50
        Projects
        Colloquia
        Seminars