22FI48 - Principles of Drug Synthesis in Pharmaceutical Engineering
Course specification | ||||
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Course title | Principles of Drug Synthesis in Pharmaceutical Engineering | |||
Acronym | 22FI48 | |||
Study programme | ||||
Module | ||||
Lecturer (for classes) | ||||
Lecturer/Associate (for practice) | ||||
Lecturer/Associate (for OTC) | ||||
ESPB | 4.0 | Status | ||
Condition | Organic Chemistry I and II | Облик условљености | ||
The goal | Introduce students to the fundamental principles of drug synthesis, from choosing pharmacologically active substances to designing and conducting the research as well as scaling up the synthetic procedure from laboratory conditions to industrial synthesis. | |||
The outcome | The students will become acquainted with fundamental drug synthesis in the pharmaceutical industry as well as research and development for industrial production. | |||
Contents | ||||
Contents of lectures | The course introduces students to the basic principles of drug synthesis, including but not limited to chemical nature and reaction mechanism, the choice of the reaction route, reactants, solvents, and product purification. The course emphasizes the methods for preparing optically clean substances. It also covers chemical methods, stereoselectivity, and catalysis, as well as the application of enzymes. Students will be introduced to asymmetric synthesis through examples from industrial practice following new stereochemical methods. The course also includes an explanation of new QSAR methods as well as the fundamental AMET characteristics of drugs. | |||
Contents of exercises | Students will synthesize pharmacologically active substances according to a literature survey and follow the reaction course using modern instrumental methods for product identification. | |||
Literature | ||||
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Number of hours per week during the semester/trimester/year | ||||
Lectures | Exercises | OTC | Study and Research | Other classes |
2 | 2 | |||
Methods of teaching | Lectures and laboratory practice. | |||
Knowledge score (maximum points 100) | ||||
Pre obligations | Points | Final exam | Points | |
Activites during lectures | 30 | Test paper | ||
Practical lessons | 20 | Oral examination | 50 | |
Projects | ||||
Colloquia | ||||
Seminars |