14D185 - Tissue Engineering

Course specification
Course titleTissue Engineering
Study programme
Lecturer (for classes)
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      ConditionОблик условљености
      The goalThe aim of the course is to introduce to students basic principles of tissue engineering as a new multidisciplinary field attractive for potential applications in medicine. In specific, the course reviewes current trends and approaches in this field followed by practical methods for laboratory work under sterile conditions and demonstartions of isolation and manipulation of cells and tissues, as well as design and set up of tissue engineering systems based on cells, biomaterials and bioreactors.
      The outcome1. Students gained knowledge of basic principles of cell and tissue functions as well as understanding of key requirements for design of tissue engineering systems. ; 2. Students gained main knowledge and practical skills required for sterile laboratory work with cell and tissue cultures. ; 3. Students gained competencies to compose and performe by themselves an experimental plan as well as to analyze and present the obtained data. ; 4. Students gained communication skills needed for work in multidisciplinary teams of engineers, biologists, pharmacists and medical doctors.
      Contents of lecturesThe course introduces to students current methods in tissue engineering for potential clinical applications. The focus is put to the approach based on integrated use of autologous cells, biocompatible and biodegradable scaffolds, and bioreactor systems for in vitro cultivation of functional tissue equivalents. Examples of tissue engineering of skin, articular cartilage, bone, ligaments, liver, miocardium, and blood vessels are described in more detail.
      Contents of exercisesIn the frame of practical work, the students can use bovine calf articular chondrocytes, and choose among several hydrogel types (e.g. alginate, polyvinil alcohol), and several bioreactor systems (e.g. perfusion bioreactor, packed bed bioreactor, a bioreactor with dynamic compression). The students learn how to isolate cells from the tissue and then apply suitable cell immobilization technique, and set up a bioreactor system. The students present their results and a review of tissue engineering approaches of a selected tissue in a written report, followed by an oral presentation.
      1. Course material
      2. Culture of Cells for Tissue Engineering, G. Vunjak-Novakovic and R.I. Freshney, eds., John Wiley & Sons, Hoboken, NJ, 2006.
      3. Group of authors "Cell and Tissue Engineering", Obradović B. (Ed.), Springer-Verlag, Berlin, Heidelberg, Germany, Academic Mind, University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia, 2011 (AM), 2012 (Springer).
      Number of hours per week during the semester/trimester/year
      LecturesExercisesOTCStudy and ResearchOther classes
      Methods of teachinglectures, laboratory work
      Knowledge score (maximum points 100)
      Pre obligationsPointsFinal examPoints
      Activites during lecturesTest paper
      Practical lessonsOral examination50