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22D49 - Bioinorganic chemistry

Course specification
Course titleBioinorganic chemistry
Acronym22D49
Study programmeBiochemical Engineering and Biotechnology,Chemistry
Module
Lecturer (for classes)
Lecturer/Associate (for practice)
Lecturer/Associate (for OTC)
    ESPB5.0Status
    ConditionОблик условљености
    The goalThe objective of the course is to provide students with knowledge about the role of metal ions in biological systems, ligands with which the metal ions have coordinatve bonds, the role of metal-protein, electron transfer processes, oxygen transport and storage, and atmospheric nitrogen fixation.
    The outcomeOn successful completion of the course, students will be able to: a) apply basic chemical principles in the explaination of the role of metal ions in biological systems, b) successfully select hysicochemical methods for studying a particular biological phenomenon, c) critically analyze the own experimental data, d) critically analyze the literary data and apply them in reaching own conclusions; e) clearly formulate the problem and suggests a way to solve it. • Identify the appropriate analytical techniques that are useful in characterizing transition-metal complexes in biological molecules. • Describe the different processes involved in the transport and storage of metal ions. • Describe the role of metal ions that are involved in electron-transfer reactions in biological systems. • Describe the most common metal centers for electron-transfer reactions—those based on copper and iron ions. • Summarize the role of metal centers in the enzymes that are involved in the nitrogen cycle. • Describe how oxygen is transported through the human body and transferred to each biological entity that requires it; identify which metal centers perform these tasks. • Describe the different metal-activation sites in enzymes that are involved in the incorporation of oxygen atoms into bio-organic molecules.
    Contents
    Contents of lecturesThe course discusses the role of metal ions in biological processes as well as the types of ligands that occur in these processes. The role of metal-proteins, ie proteins activated by the presence of metals in hydrolytic processes, in electron transfer processes, as well as in oxygen transport and storage in biological systems is discussed. More important ways of fixing atmospheric nitrogen are also being considered. - Review of physical methods as applied to bioinorganic chemistry - Proteins as ligands: how the amino acids bind to metals - Zinc enzymes: carbonic anhydrase, carboxypeptidase A, phospotriesterase - Calcium binding proteins: Calmodulin - Hydrogenase and its mimics -Oxygen transport and activation: hemocyanin, methane monooxgenase - Non heme iron sites in enzymes: ribonucleotide reductase - Superoxide Dismutase (including the recently discovered Ni SOD - Nitrogenase and its mimics - Electron transport proteins: blue copper proteins, cytochrome P450 - The role of Co and Ni dependent enzymes in ancient life; Cobalamins: organometallic bonds in enzymes - Ni enzymes: Acetyl-CoA Synthase and CO dehydrogenase - Student presentations on selected topics - Metal containing drugs: cisplatin - Metal toxicity: lead and cadmium
    Contents of exercisesAnalysis of a bioinorganic system based on a review of the literature.
    Literature
    1. Rosette M. Roat-Malone, Bioinorganic Chemistry: A Short Course, 3rd Edition, Wiley (2020); ISBN: 978-1-119-53526-3
    Number of hours per week during the semester/trimester/year
    LecturesExercisesOTCStudy and ResearchOther classes
    31
    Methods of teachingLectures,seminar, tests
    Knowledge score (maximum points 100)
    Pre obligationsPointsFinal examPoints
    Activites during lectures10Test paper
    Practical lessonsOral examination50
    Projects
    Colloquia
    Seminars40